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Updated: Aug 15, 2026
The Influence of Liver Resection on Intrahepatic Tumor Growth
Published on: April 9, 2016
[Effects of octreotide on implanted liver tumor after partial hepatectomy in rats]
1Department of General Surgery, Anhui Provincial People's Hospital, Hefei 230001, China.
Objectives:
To investigate the effects of octreotide(OCT) on experimental live tumor after partial hepatectomy (PH) in rats and explore its intrinsic mechanism.
Methods:
Sixty-four male rats were randomly divided into four groups and operated on with laparotomy. Walker-256 tumor was implanted in all the four groups. Group A served as the control, and groups B, C and D received left lobe PH. Octreotide at a dose of 50 microg/kg was intraperitoneally (i.p.) administered twice a day in groups C and D (OCT). The time of the first administration was at the 12th hour after PH in group C and the 72nd hour after PH in group D. The rats in groups A and B received a similar volume of normal saline (NS).
Results:
Group A showed a significant reduction of implanted liver tumor volume at the 7th day versus group B (P < 0.01). Groups C and D showed a significant reduction of tumor volume at the 7th and 15th day versus group B (P < 0.01). The tumor cell apoptotic rate was significantly higher in groups C and D than in groups A and B at the 7th and 15th day (P < 0.01).
Conclusion:
The growth of experimental liver tumor is enhanced after PH bat can be inhibited by OCT.
