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Related Experiment Videos

Cortical mechanisms mediating asterixis.

J Artieda1, J Muruzabal, R Larumbe

  • 1Department of Neurology, Clinica Universitaria, University of Navarra, Pamplona, Spain.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1992
PubMed
Summary
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This study documents a patient with chronic renal failure experiencing asterixis, a type of jerk. Findings suggest a common origin in the sensorimotor cortex for these movements.

Area of Science:

  • Neuroscience
  • Nephrology

Background:

  • Asterixis, or 'flapping tremor,' is a motor disorder characterized by sudden, brief muscle jerks.
  • This condition is often associated with metabolic encephalopathies, including those secondary to chronic renal failure.

Observation:

  • A patient with chronic renal failure presented with multifocal action-induced jerks consistent with asterixis.
  • Electromyography (EMG) confirmed the characteristic silent periods of asterixis.
  • Electroencephalography (EEG) revealed a biphasic wave preceding asterixis by 23 ms.
  • Somatosensory evoked potentials (SEPs) were pathologically enlarged in both hemispheres following median nerve stimulation.

Findings:

  • Brain mapping indicated a shared origin in the sensorimotor cortex for both the pre-asterixis EEG wave and the enlarged SEPs.

Related Experiment Videos

  • This suggests a cortical basis for the observed asterixis in this patient.

    • Implications:

    • Provides evidence for a cortical origin of certain types of asterixis in humans.
    • Highlights the utility of combined EEG, EMG, and SEP analysis in understanding movement disorders associated with renal failure.