Related Experiment Video
Updated: Aug 15, 2026
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
[Analysis on prognostic factors of liver failure in children]
Shi-shu Zhu1, Hong-fei Zhang, Ju-mei Chen
1Department of Pediatric Liver Diseases, The No 302 Hospital of The People's Liberation Army, Beijing, China.
Insights
Pediatric liver failure has a high mortality rate. Prothrombin activity (PTA) and total bilirubin (TBIL) levels are key indicators for improving survival rates in children with liver failure.
Area of Science:
- Pediatric Hepatology
- Clinical Medicine
- Biochemistry
Context:
- Liver failure in children presents a significant clinical challenge.
- Retrospective analysis of 105 pediatric cases over 17 years.
- High mortality rate underscores the need for prognostic indicators.
Purpose:
- To identify prognostic factors influencing mortality in pediatric liver failure.
- To analyze clinical and biochemical markers associated with survival.
- To determine independent risk factors for poor outcomes.
Summary:
- Mortality rate for pediatric liver failure was 68.6% in the studied cohort.
- Univariate analysis identified age, clinical stage, prothrombin activity (PTA), albumin (AIB), total bilirubin (TBIL), and hepatic encephalopathy as significant factors.
- Multivariate analysis revealed PTA and TBIL as independent predictors of mortality.
Impact:
- Findings highlight the critical role of PTA and TBIL in assessing prognosis.
- Early identification of these markers can guide timely diagnosis and treatment.
- Improved management strategies based on these indicators may enhance survival rates in pediatric liver failure.
Objective:
To analyze the prognostic factors of liver failure in children.
Methods:
The clinical data of 105 children with liver failure treated in the No. 302 Hospital in the past 17 years were retrospectively analyzed. The related factors were analysed by EXCELL 2000 and STATA 7.0, multivariate statistical analysis was performed by Logistic regression.
Results:
(1) A total of 72 children died and the mortality was 68.6%. (2) Univariate statistical analysis showed that the factors significantly correlated with death were age, clinical type and stage of liver failure, decrease in prothrombin activity (PTA) and albumin (AIB) level, increase in serum level of total bilirubin (TBIL), appearance of deviation of TBIL and ALT, complications and hepatic encephalopathy. There was no significant difference between boys and girls. (3) There was no significant difference among etiological diagnoses such as HBV infection, Wilson's disease, and unknown pathogeny. (4) Multivariate statistical analysis showed that PTA (P = 0.000) and TBIL (P = 0.029) were independent risk factors of mortality of the children.
Conclusion:
The prognosis of liver failure in children is poor and mortality is high. PTA and TBIL might be useful for indicating prompt diagnosis and treatment to improve survival rate of the children with liver failure.
Related Concept Videos
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution