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[Hemorheologic changes in patients with chronic hepatitis B].

Yan Yang1, Kai Wang, Li-yan Han

  • 1Department of Liver Disease, Qilu Hospital, Shandong University, Jinan 250012, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|October 6, 2005
PubMed
Summary

Chronic hepatitis B patients show altered hemorheology and oxidative stress, indicating microcirculation disturbances. These factors, alongside HBV DNA, are crucial for patient assessment.

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Area of Science:

  • Hepatology and Gastroenterology
  • Hematology
  • Biochemistry

Context:

  • Chronic hepatitis B is a significant global health concern.
  • Understanding hemorheological changes and oxidative stress in hepatitis B is crucial for managing disease progression and complications.

Purpose:

  • To investigate hemorheological variations in chronic hepatitis B patients.
  • To explore the relationship between hemorheology, HBV DNA levels, liver function (ALT), and oxidative stress markers.

Summary:

  • Patients with chronic hepatitis B exhibited significantly higher low-shear whole blood viscosity (BV) and red blood cell (RBC) aggregation index compared to controls.
  • Elevated hematocrit (HCT), low-shear BV, and RBC aggregation index were observed in patients with higher ALT levels.
  • No significant correlations were found between hemorheology indices and HBV DNA or oxidative stress markers.

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Impact:

  • The study highlights microcirculatory disturbances and oxidative stress in chronic hepatitis B.
  • Hemorheology and oxidative stress markers may serve as valuable adjunct indicators for assessing chronic hepatitis B patients, complementing HBV DNA markers.