Related Experiment Video
Updated: Aug 15, 2026

Transient Treatment of Human Pluripotent Stem Cells with DMSO to Promote Differentiation
Published on: July 17, 2019
The molecular basis of transdifferentiation
Wan-Chun Li1, Wei-Yuan Yu, Jonathan M Quinlan
1Centre for Regenerative Medicine, Department of Biology & Biochemistry, University of Bath, Claverton Down, Bath, UK.
Abstract:
There is now excellent experimental evidence demonstrating the remarkable ability of some differentiated cells to convert to a completely different phenotype. The conversion of one cellular phenotype to another is referred to as 'transdifferentiation' and belongs to a wider class of cell-type switches termed 'metaplasias'. Defining the molecular steps in transdifferentiation will help us to understand the developmental biology of the cells that interconvert, as well as help identify key regulatory transcription factors that may be important for the reprogramming of stem cells. Ultimately, being able to produce cells at will offers a compelling new approach to therapeutic transplantation and therefore the treatment and cure of diseases such as diabetes.
More Related Videos
09:32Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
Published on: June 15, 2017
14:43Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
Published on: October 1, 2012
Related Concept Videos
Forced Transdifferentiation
Artificial transdifferentiation occurs...
Cellular Differentiation
A zygote is a...
Methods of Nuclear Reprogramming
Overview of Transposition and Recombination
Transgenic Organisms
General Transcription Factors