Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MARCKS for maintenance in dendritic spines.

Andrew Matus1

  • 1Friedrich Miescher Institute, Maulbeerstrasse 66, 4058 Basel, Switzerland.

Neuron
|October 6, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging actin in tissue slices from transgenic mouse brain.

CSH protocols·2011
Same author

Transfecting Cultured Hippocampal Neurons with an Actin-GFP Plasmid.

CSH protocols·2011
Same author

Munc18 and Munc13 regulate early neurite outgrowth.

Biology of the cell·2010
Same author

Interactions between drebrin and Ras regulate dendritic spine plasticity.

The European journal of neuroscience·2008
Same author

Time-lapse imaging of dendritic spines in vitro.

Nature protocols·2007
Same author

Reversible, activity-dependent targeting of profilin to neuronal nuclei.

Experimental cell research·2006

The protein MARCKS is crucial for maintaining dendritic spine stability in the brain. This research highlights its role in balancing synaptic plasticity and reliable brain function.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Synaptic function requires a balance between plasticity for learning and stability for reliability.
  • Dendritic spines are critical structures for synaptic transmission and plasticity.

Purpose of the Study:

  • To investigate the role of the protein MARCKS in maintaining dendritic spine structure and function.
  • To understand how MARCKS contributes to the balance between synaptic plasticity and stability.

Main Methods:

  • Cell-transfection experiments were utilized.
  • The binding properties of MARCKS to the cell surface and actin cytoskeleton were examined.

Main Results:

  • MARCKS protein was implicated in the maintenance of dendritic spines.

Related Experiment Videos

  • MARCKS's ability to bind to both the cell surface and actin cytoskeleton is central to its function.

    • Conclusions:

    • MARCKS plays a significant role in stabilizing dendritic spines.
    • Understanding MARCKS's function provides insights into maintaining overall brain function and learning processes.