Related Experiment Videos
D-aspartate and reproductive activity in sheep
R Boni1, R Santillo, G Macchia
1Department of Animal Science, University of Basilicata, Campus Macchia Romana, 85100 Potenza, Italy. boni@unibas.it
Theriogenology
|October 6, 2005
Summary
D-aspartic acid (D-Asp) is found in sheep tissues and can be converted to N-methyl-D-aspartic acid (NMDA). D-Asp administration increased LH levels, suggesting a role in sheep reproductive activity.
Area of Science:
- Neuroendocrinology
- Reproductive Biology
- Amino Acid Metabolism
Background:
- D-aspartic acid (D-Asp) is present in neuroendocrine tissues.
- D-Asp may be converted to N-methyl-D-aspartic acid (NMDA), a neuromodulator linked to sexual activity.
Purpose of the Study:
- To determine D-Asp and NMDA concentrations in ewe tissues after D-Asp administration.
- To evaluate the effect of D-Asp administration on reproductive activity in ewes.
Main Methods:
- D-Asp and NMDA levels were measured in endocrine glands and other tissues in ewes.
- Reproductive activity was assessed by measuring progesterone and LH pulses.
- D-Asp was administered subcutaneously, and plasma levels were monitored.
Main Results:
- The pineal gland had the highest natural D-Asp content; the pituitary gland showed the highest storage capacity after administration.
- NMDA levels significantly increased in the pituitary and brain 12 hours after D-Asp administration.
- D-Asp administration significantly increased LH levels, but did not induce reproductive activity in acyclic ewes.
Conclusions:
- D-aspartic acid is endogenously present in sheep and is selectively stored in endocrine glands and brain tissue.
- Increased NMDA and LH following D-Asp administration suggest a role for this amino acid in sheep reproductive function.
- Further research is needed to fully elucidate the role of D-Asp in sheep reproduction.