Search research articles

Search research articles

Related Experiment Videos

Changes of selected hematologic parameters during long-term immunoadsorption therapy.

¹Blood Center of University Hospital, 17 listopadu 833, 708 52 Ostrava-Poruba, Czech Republic. jan.ptak@fnspo.cz

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|October 6, 2005

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Using the World Apheresis Association Registry Helps to Improve the Treatment Quality of Therapeutic Apheresis.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2021

Same author

WAA apheresis registry in the Czech Republic: two centers experience.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2009

Same author

World apheresis registry data from 2003 to 2007, the pediatric and adolescent side of the registry.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2008

Same author

Chronic pain and occupation: an exploration of the lived experience.

The American journal of occupational therapy : official publication of the American Occupational Therapy Association·2007

Same author

World apheresis registry report.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2007

Same author

Recombinant coagulation factor VIIa in the management of bleeding in patients with von Willebrand disease type 2A.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2004

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Immunoadsorption therapy for myasthenia gravis caused temporary drops in hemoglobin and platelets, with initial increases in leukocytes. Long-term treatment may lead to immunosuppression, indicated by reduced leukocyte responses.

Area of Science:

Hematology
Immunology
Neurology

Background:

Myasthenia gravis is an autoimmune disorder affecting neuromuscular junctions.
Immunoadsorption is a therapeutic apheresis technique used to remove pathogenic antibodies.

Purpose of the Study:

To investigate hematologic parameter changes in patients with myasthenia gravis undergoing immunoadsorption therapy.
To explore potential immunomodulatory effects of long-term immunoadsorption.

Main Methods:

Analysis of complete blood counts (hemoglobin, platelets, leukocytes) before and after immunoadsorption procedures.
Longitudinal monitoring of hematologic parameters in six myasthenia gravis patients over a mean treatment duration of 18.6 months.

Main Results:

Related Experiment Videos

A consistent decrease in hemoglobin (median -7.27%) and platelet counts (median -5.63%) was observed after each procedure.
Leukocyte counts initially increased (median 6.63%) post-procedure.
In three patients, leukocyte count increases diminished with cumulative treatment, suggesting an immunosuppressive effect.

Conclusions:

Short-term immunoadsorption for myasthenia gravis leads to transient reductions in hemoglobin and platelets, potentially due to blood sampling and residual volumes.
Long-term immunoadsorption therapy may induce an immunosuppressive effect, as evidenced by a blunted leukocyte response over time.