Related Experiment Video

Updated: Jun 20, 2026

Pseudofracture: An Acute Peripheral Tissue Trauma Model
10:08

Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

Fracture and non-fracture pain in children with osteogenesis imperfecta

Philip Zack1, Linda Franck, Catherine Devile

  • 1North West Thames Regional Genetics Service, Harrow, United Kingdom. p.zack@virgin.net

Acta Paediatrica (Oslo, Norway : 1992)
|October 6, 2005
PubMed

Insights

Children with osteogenesis imperfecta (OI) experience significant acute fracture pain and chronic non-fracture pain, impacting daily activities. Current pain management strategies may be insufficient, as many children report moderate to severe pain despite treatment.

Area of Science:

  • Pediatric Rheumatology
  • Pain Management
  • Genetics

Background:

  • Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by brittle bones.
  • Chronic pain is a significant challenge for children with OI, affecting their quality of life.

Purpose of the Study:

  • To characterize and compare acute fracture pain with chronic non-fracture pain in pediatric patients with OI.
  • To identify differences in pain intensity, quality, coping mechanisms, and treatment efficacy.

Main Methods:

  • A prospective study involving 35 children (aged 5-18) with OI from a UK national service.
  • Utilized questionnaires for fracture pain and 7-day diaries for non-fracture pain, assessing pain intensity, location, quality, coping, and analgesia use.

Main Results:

  • Fracture pain was more intense and affected daily activities more than non-fracture pain (p<0.001).
  • Affective descriptors were less common for non-fracture pain (p=0.002).
  • Children used different coping strategies for fracture (approach) versus non-fracture (distraction) pain (p<0.01).

Conclusions:

  • Pain is prevalent in children with OI, manifesting as both acute and chronic conditions that impair daily functioning.
  • Existing pain management, including analgesics and coping strategies, appears suboptimal for many children with OI.
  • Bisphosphonate treatment did not significantly alter non-fracture pain characteristics.
Abstract

More Related Videos

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects07:35

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

Published on: April 11, 2012

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents06:59

Fracture Apparatus Design and Protocol Optimization for Closed-stabilized Fractures in Rodents

Published on: August 14, 2018

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...