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Related Experiment Videos

Impaired endothelial function in patients with ankylosing spondylitis.

I Sari1, T Okan, S Akar

  • 1Department of Internal Medicine, Division of Rheumatology, Department of Cardiology, Dokuz Eylul University School of Medicine, Izmir, Turkey. ismail.sari@deu.edu.tr

Rheumatology (Oxford, England)
|October 6, 2005
PubMed
Summary

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Ankylosing spondylitis patients show impaired endothelial function, indicating a higher cardiovascular risk. This study highlights the importance of monitoring vascular health in these individuals.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Rheumatic diseases like rheumatoid arthritis and systemic lupus erythematosus are linked to accelerated atherosclerosis and increased cardiovascular events.
  • The relationship between inflammation, atherosclerosis, and ankylosing spondylitis (AS) remains controversial.
  • AS is a chronic inflammatory condition primarily affecting the spine.

Purpose of the Study:

  • To evaluate the degree of atherosclerosis and endothelial function in patients with ankylosing spondylitis (AS).
  • To investigate the link between inflammation and vascular health in AS.
  • To utilize ultrasonography for assessing vascular parameters in AS patients.

Main Methods:

  • Fifty-four AS patients and 31 healthy controls were enrolled.

Related Experiment Videos

  • Serum lipids, creatinine, glucose, and acute-phase proteins were measured.
  • Vascular parameters including flow-mediated dilatation (FMD) and intima-media thickness (IMT) of the brachial artery and common carotid artery were assessed sonographically.

    • Main Results:

    • No significant difference in common carotid artery intima-media thickness (IMT) was observed between AS patients and controls.
    • Flow-mediated dilatation (FMD) was significantly lower in AS patients compared to controls (P=0.03).
    • Nitroglycerin-induced dilatation was also lower in AS patients, though not statistically significant (P=0.07).

    Conclusions:

    • This study demonstrates impaired endothelial function in ankylosing spondylitis patients.
    • The findings suggest a potential increased cardiovascular risk in individuals with AS.
    • Endothelial dysfunction may be an early indicator of vascular involvement in AS.