Related Experiment Video
Updated: Aug 15, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Viral strategies for evading antiviral cellular immune responses of the host
Alexandre Iannello1, Olfa Debbeche, Elodie Martin
1Ste-Justine Hospital Research Center, Department of Microbiology and Immunology, University of Montreal, Quebec, Canada.
Abstract:
The host invariably responds to infecting viruses by activating its innate immune system and mounting virus-specific humoral and cellular immune responses. These responses are aimed at controlling viral replication and eliminating the infecting virus from the host. However, viruses have evolved numerous strategies to counter and evade host's antiviral responses. Providing specific examples from the published literature, we discuss in this review article various strategies that viruses have developed to evade antiviral cellular responses of the host. Unraveling these viral strategies allows a better understanding of the host-pathogen interactions and their coevolution. This knowledge is important for identifying novel molecular targets for developing antiviral reagents. Finally, it may also help devise new knowledge-based strategies for developing antiviral vaccines.
Related Concept Videos
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Viruses with RNA Genomes
Inhibitors of Viral Protein Synthesis
Antiviral Nucleoside Inhibitors
Retrovirus Life Cycles
Size and Structure of Viral Genomes

