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Cough sensitivity in allergic rhinitis.

R Pecova¹, M Vrlik, M Tatar

¹Department of Pathophysiology, Jessenius Medical School, Comenius University, Martin, Slovakia. pecova@jfmed.uniba.sk

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society

|October 6, 2005

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Pollen-sensitive individuals with allergic rhinitis exhibit heightened capsaicin cough sensitivity. This increased cough reflex persists even outside of pollen season, suggesting underlying airway inflammation.

Area of Science:

Respiratory Medicine
Immunology
Clinical Allergy

Background:

Allergic rhinitis is a common condition affecting the upper airways.
Seasonal variations in pollen exposure can impact respiratory symptoms.
Cough sensitivity is a potential indicator of airway hyperresponsiveness.

Purpose of the Study:

To assess capsaicin cough sensitivity in patients with seasonal allergic rhinitis.
To compare cough reflex sensitivity during and outside of grass pollen season.
To investigate the relationship between allergic rhinitis and airway hyperresponsiveness.

Main Methods:

Capsaicin cough challenge was used to determine cough reflex sensitivity (C2).
Participants included pollen-sensitive patients with allergic rhinitis and healthy controls.

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Measurements were taken both during and out of the grass pollen season.

Main Results:

Pollen-sensitive patients showed significantly lower C2 values compared to healthy controls.
Cough sensitivity was elevated in allergic rhinitis patients irrespective of pollen season.
A trend towards even greater sensitivity during pollen season was observed.

Conclusions:

Seasonal allergic rhinitis is associated with enhanced capsaicin cough sensitivity.
This heightened sensitivity may be due to subclinical inflammation in the lower airways.
Cough reflex sensitivity is a relevant marker in allergic rhinitis management.