Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrafractional motion during proton beam scanning.

J Lambert1, N Suchowerska, D R McKenzie

  • 1School of Physics, The University of Sydney, NSW 2006, Australia. jlambert@Physics.usyd.edu.au

Physics in Medicine and Biology
|October 6, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermodynamic Interpretation of the Meyer-Neldel Rule Explains Temperature Dependence of Ion Diffusion in Silicate Glass.

Physical review letters·2022
Same author

Extending the Debye scattering equation for diffraction from a cylindrically averaged group of atoms: detecting molecular orientation at an interface.

Acta crystallographica. Section A, Foundations and advances·2020
Same author

Sensory gating in bilayer amorphous carbon memristors.

Nanoscale·2018
Same author

Graphitization of Glassy Carbon after Compression at Room Temperature.

Physical review letters·2018
Same author

Predator-prey dynamics stabilised by nonlinearity explain oscillations in dust-forming plasmas.

Scientific reports·2016
Same author

Reaction paths of phosphine dissociation on silicon (001).

The Journal of chemical physics·2016

Patient motion during proton beam therapy can cause significant dose errors. Different scanning methods and motion directions impact the final dose distribution, potentially delivering under or overdoses to the target volume.

Area of Science:

  • Medical Physics
  • Radiation Oncology

Background:

  • Patient and internal organ motion during scanned proton beam therapy can cause dose distribution heterogeneities.
  • Traditional static beam techniques use margins to account for motion, which may be insufficient for dynamic scanning.

Purpose of the Study:

  • To investigate the impact of intrafractional motion on dose distribution in scanned proton beam therapy.
  • To evaluate the effects of motion direction and scanning methods on dose accuracy.

Main Methods:

  • Simulated intrafractional motion parallel and perpendicular to the beam axis using two scanning methods.
  • Experiments conducted on a cubic water phantom to assess dose distribution changes.

Main Results:

  • The direction of motion relative to the beam scanning direction significantly affects dose distribution.

Related Experiment Videos

  • The scanning method employed also has a considerable impact on the resulting dose within the target volume.
  • In extreme cases, up to 100% of the target volume received doses outside recommended limits, with minimum doses as low as 34% of the prescribed dose.

    • Conclusions:

    • Intrafractional motion poses a significant challenge to dose accuracy in scanned proton beam therapy.
    • Both motion direction and scanning strategy are critical factors influencing dose delivery accuracy.
    • Current motion compensation strategies may need re-evaluation for dynamic scanning techniques to ensure adequate dose coverage and avoid toxicity.