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Lipid, lipoprotein, apolipoprotein and lipoprotein(a) levels: reference intervals in a healthy Indian population

Tester F Ashavaid1, Altaf A Kondkar, Seema P Todur

  • 1Research Laboratories, P. D. Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai 400-016, India. dr_tashavaid@hindujahospital.com

Journal of Atherosclerosis and Thrombosis
|October 6, 2005
PubMed

Insights

This study establishes crucial reference intervals for major apolipoproteins (apos) in healthy Indian adults, aiding in coronary artery disease (CAD) risk assessment for lipids and lipoproteins.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Lipidology

Background:

  • The role of lipids and lipoproteins in coronary artery disease (CAD) is established, yet the significance of major apolipoproteins (apos) beyond apo A-I and apo B requires further elucidation.
  • Understanding apolipoprotein profiles is essential for comprehensive cardiovascular risk stratification.

Purpose of the Study:

  • To establish reference intervals for major apolipoproteins (apos) in a healthy Indian population.
  • To investigate the influence of demographic factors like age, smoking, and alcohol consumption on these apolipoprotein levels.

Main Methods:

  • Serum levels of total cholesterol, HDL-C, LDL-C, triglycerides, LDL-apoB, and major apos (A-I, A-II, B, C-II, C-III, E) were quantified using immunoturbidimetry.
  • Percentiles and reference intervals were determined for 751 healthy Indian subjects (470 men, 281 women, aged 25-65 years).

Main Results:

  • This study presents the first comprehensive reference intervals for all major apolipoproteins in both sexes within a general Indian population.
  • Established reference intervals and percentile data for key lipid and apolipoprotein analytes.
  • Evaluated the impact of age, smoking, and alcohol on measured analytes.

Conclusions:

  • The established reference intervals for major apolipoproteins are clinically relevant for assessing coronary artery disease (CAD) risk.
  • These findings provide a valuable resource for clinicians managing patients with hyperlipidemia and related conditions.

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