Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

14.7K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.7K
Responses to Salt Stress02:02

Responses to Salt Stress

14.5K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.5K
General State of Stress01:21

General State of Stress

633
The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
633
Stress01:20

Stress

8.6K
When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
8.6K
Stress Prevention and Stress Management Techniques II01:23

Stress Prevention and Stress Management Techniques II

508
Personality types, particularly Type A and Type B, significantly influence how individuals respond to stress. These personality distinctions are marked by varying levels of ambition, competitiveness, and coping styles, all of which shape an individual's resilience to stressors.
Type A Personality: Driven and Easily Stressed
Individuals with Type A personalities are often highly competitive and ambitious and operate with a strong sense of urgency. Commonly labeled as...
508
Stress Prevention and Stress Management Techniques I01:26

Stress Prevention and Stress Management Techniques I

294
Stress prevention and management are crucial for maintaining well-being and building resilience. Techniques to manage stress include cultivating qualities like conscientiousness, a sense of personal control, and self-efficacy. Each of these traits significantly reduces stress and promotes healthier lifestyle choices and outcomes.
Conscientiousness
Conscientious individuals tend to be organized, responsible, and disciplined. They prioritize completing tasks and following structured routines,...
294

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping administration route-dependent transduction profiles of commonly used AAV variants in mice by barcode amplicon sequencing.

Molecular therapy. Methods & clinical development·2025
Same author

Suppression of toxic transgene expression by optimized artificial miRNAs increases AAV vector yields in HEK-293 cells.

Molecular therapy. Methods & clinical development·2024
Same author

Retrospective study of tetanus in 18 dogs-Causes, management, complications, and immunological status.

Frontiers in veterinary science·2023
Same author

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex.

Nature communications·2022
Same author

Identification of Broadly Applicable Adeno-Associated Virus Vectors by Systematic Comparison of Commonly Used Capsid Variants <i>In Vitro</i>.

Human gene therapy·2022
Same author

Molecular Nutrition & Food Research - Functional Relevance of Dietetics and Its Impact on Gut Microbiome, Inflammation and Obesity.

Molecular nutrition & food research·2022
Same journal

ALDH18A1 fuels spermine biosynthesis to sustain ferroptosis resistance in cancer and ischemia-reperfusion injury.

Cell cycle (Georgetown, Tex.)·2026
Same journal

Circular RNA circ_0001829 attenuates G2/M arrest to promote hepatocyte proliferation by sponging miR-3095-3p following liver injury.

Cell cycle (Georgetown, Tex.)·2026
Same journal

Identification of PGF+ endothelial cells associated with plaque instability in carotid atherosclerosis by scRNA-seq and RNA-seq analysis.

Cell cycle (Georgetown, Tex.)·2026
Same journal

BMSCs-derived exosomal miR-196a-5p promotes macrophage M2 polarization and osteogenesis in postmenopausal osteoporosis through regulating Rspo2/Wnt/β-catenin signaling.

Cell cycle (Georgetown, Tex.)·2026
Same journal

MicroRNA-6833-3p drives prostate cancer progression and stemness by targeting the NUMB-mediated NOTCH signaling pathway.

Cell cycle (Georgetown, Tex.)·2026
Same journal

OTUD5 promotes AML progression by stabilizing SLC7A11 to suppress ferroptosis.

Cell cycle (Georgetown, Tex.)·2026
See all related articles

Related Experiment Video

Updated: Jan 23, 2026

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
10:57

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress

Published on: October 13, 2019

8.0K

Cellular stress and nucleolar function.

Christine Mayer1, Ingrid Grummt

  • 1Division of Molecular Biology of the Cell II, German Cancer Research Center, Heidelberg, Germany. ChristineMayer@dkfz.de

Cell Cycle (Georgetown, Tex.)
|October 6, 2005
PubMed
Summary
This summary is machine-generated.

The nucleolus, not just for ribosomes, actively monitors and responds to cellular stress. It regulates ribosomal RNA synthesis by controlling transcription factor TIF-IA, crucial for cell survival during stress.

More Related Videos

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

8.6K
Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
11:04

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast

Published on: June 23, 2018

7.6K

Related Experiment Videos

Last Updated: Jan 23, 2026

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress
10:57

Examining the Dynamics of Cellular Adhesion and Spreading of Epithelial Cells on Fibronectin During Oxidative Stress

Published on: October 13, 2019

8.0K
Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
09:38

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry

Published on: June 26, 2019

8.6K
Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
11:04

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast

Published on: June 23, 2018

7.6K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Stress Response

Background:

  • Organisms possess mechanisms to maintain homeostasis under stress.
  • The nucleolus was traditionally viewed solely as a ribosome production site.

Purpose of the Study:

  • To review current research on the nucleolus's role in cellular stress response.
  • To elucidate the molecular mechanisms by which the nucleolus senses and reacts to stress.

Main Methods:

  • Review of existing studies on nucleolar function under stress conditions.
  • Analysis of the regulation of ribosomal RNA (rRNA) synthesis.
  • Investigation of the role of transcription factor TIF-IA and its interaction with RNA polymerase I (Pol I).

Main Results:

  • Cells down-regulate rRNA synthesis upon exposure to stress.
  • Nucleolar stress response involves structural changes, cell cycle arrest, and p53 stabilization.
  • Stress phosphorylates TIF-IA via JNK2, inhibiting Pol I activity and rRNA synthesis.
  • Inactivated TIF-IA translocates from the nucleolus to the nucleoplasm.

Conclusions:

  • The nucleolus is a critical sensor and mediator of cellular stress response.
  • Nucleolar proteins, including TIF-IA, play dynamic regulatory roles beyond ribosome biogenesis.
  • These findings highlight the nucleolus's central role in orchestrating cellular adaptation to stress.