[Sedation and study of hormone dynamics in patients with severe brain injury during early postoperative period]

The paper presents the results of an investigation of the effect of sodium oxybutyrate, thiopental sodium, and propofol on the blood levels of cortisol, ACTH, TTH, T4 and T3 in patients with severe brain injury who have received artificial ventilation. The investigations showed that laboratory signs of the low T3-syndrome appeared by postoperative day 3 in all the patients. In patients receiving propofol, the manifestations of this syndrome were less pronounced and the parameters became normal more rapidly than in those taking oxyburate and thiopental sodium.