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Related Experiment Videos

Giant gram-negative brain abscesses. Report of two cases.

Clarence S Greene1, Michele Cheung, Josie Perdue

  • 1Neurosurgery Section, Division of Infectious Disease, and Division of Nursing, Miller Children's Hospital, Long Beach, California, USA. Clarence@kidsneurosurgery.org

Journal of Neurosurgery
|October 7, 2005
PubMed
Summary

Giant brain abscesses are rare but can occur in children with hydrocephalus and ventricular shunts. These factors can mask symptoms, leading to delayed diagnosis of large brain abscesses caused by Gram-negative pathogens.

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Area of Science:

  • Pediatric Neurosurgery
  • Infectious Diseases
  • Neuroimaging

Background:

  • Giant brain abscesses are uncommon in contemporary pediatric neurosurgery.
  • Advances in neuroimaging have improved early diagnosis of brain abscesses.
  • Complicating factors can delay diagnosis, allowing abscesses to reach extreme sizes.

Observation:

  • Two cases of giant brain abscesses in children are presented.
  • Abscesses achieved significant size before symptom manifestation.
  • Cerebrospinal fluid diversion through ventricular shunts can mask increased intracranial pressure.

Findings:

  • Causative pathogens were identified as Gram-negative bacteria of multiple species.
  • The ability of these pathogens to form large abscesses is explored.

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  • Clinical factors, including meningitis and ventricular shunts, contributed to abscess development.

    • Implications:

    • Highlights the importance of considering giant brain abscesses in specific pediatric populations.
    • Emphasizes the role of Gram-negative pathogens in severe abscess formation.
    • Underscores the need for vigilance in diagnosing brain abscesses, even with complicating factors like shunts.