Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered dendritic cell distribution in patients with common variable immunodeficiency.

Jean-François Viallard1, Fabrice Camou, Marc André

  • 1Department of Internal Medicine and Infectious Diseases, Haut-Lévêque Hospital, Pessac, France. jean-francois.viallard@chu-bordeaux.fr

Arthritis Research & Therapy
|October 7, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The IL-10/IL-6 Ratio and the Risk Score: Two Cytokines-Based Predictors for Malignancy-Associated Hemophagocytic Lymphohistiocytosis in Adults (M-HLHa).

American journal of hematology·2026
Same author

French protocol for diagnosis and management (guidelines) of IgG4-related disease.

La Revue de medecine interne·2026
Same author

Difference of Admission Neutrophil Gelatinase-Associated Lipocalin Concentration Between Patients Developing and Not Developing Acute Kidney Injury or Need for Acute Dialysis: An Ancillary Individual-Study Data Meta-Analysis (INDICATE-AKI).

Kidney medicine·2026
Same author

Characteristics and Outcomes of Operated Versus Nonoperated Patients With Infective Endocarditis and Cerebral Complications: the COOPER Study.

The Canadian journal of cardiology·2026
Same author

Increased intervals in enzyme replacement therapy for stable type 1 Gaucher disease: A non-inferiority sequential trial emulation.

Journal of internal medicine·2026
Same author

Scurvy, an enduring mimicker and diagnostic dilemma in adults: A review of the 280 relevant published cases in the twenty-first century.

Clinical nutrition (Edinburgh, Scotland)·2026

Common variable immunodeficiency (CVID) patients show altered dendritic cell (DC) distribution, particularly plasmacytoid DCs (pDCs). Reduced pDCs and myeloid DCs (mDCs) correlate with specific B cell deficits and granulomatous disease in CVID.

Area of Science:

  • Immunology
  • Cell Biology
  • Infectious Diseases

Background:

  • Dendritic cells (DCs) are crucial for adaptive immunity, particularly in generating antibody-producing plasma cells.
  • Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by impaired B cell differentiation and antibody production.
  • The specific role and distribution of DC subsets in CVID pathogenesis remain incompletely understood.

Purpose of the Study:

  • To investigate the frequency and distribution of peripheral blood plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) in adult patients with CVID.
  • To correlate DC subset alterations with B cell differentiation status (CD27 expression) and clinical phenotypes (granulomatous disease) in CVID.

Main Methods:

  • Flow cytometry analysis of peripheral blood samples from 44 adult CVID patients and healthy controls.

Related Experiment Videos

  • Classification of CVID patients based on CD27 membrane expression on B cells, specifically analyzing memory B cell subsets (CD27+IgD-IgM-).
  • Statistical comparison of DC subset frequencies between CVID patient subgroups and controls.

    • Main Results:

    • A significant alteration in DC subset distribution was observed in CVID patients, with a notable decrease in pDCs.
    • Patients with reduced class-switched memory B cells and those with granulomatous disease exhibited a dramatic decrease in both pDCs and, to a lesser extent, mDCs compared to controls.
    • CVID patients with normal numbers of switched memory B cells showed a DC distribution pattern similar to healthy individuals.

    Conclusions:

    • Peripheral blood DC subset distribution, especially pDCs, is profoundly altered in CVID patients, particularly those with specific B cell abnormalities or granulomatous disease.
    • These findings suggest a potential contribution of innate immune dysregulation, involving DCs, to the pathogenesis of CVID.
    • Further research is warranted to elucidate the precise mechanisms by which DC alterations impact CVID pathophysiology and clinical manifestations.