Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The detection of shared and ancestral polymorphisms.

Brian Charlesworth1, Carolina Bartolomé, Véronique Noël

  • 1Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King's Buildings, UK. Brian.Charlesworth@ed.ac.uk

Genetical Research
|October 7, 2005
PubMed
Summary

This study introduces a method to better estimate ancestral polymorphisms in closely related species like Drosophila. This improves understanding of genetic variation and evolutionary selection pressures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How is variation in fitness maintained?

Evolution; international journal of organic evolution·2026
Same author

Short communication: Amitraz treatments do not increase the frequency of mutations in the β2-adrenergic octopamine receptor in Varroa destructor: a field study in Central Spain.

Research in veterinary science·2026
Same author

Is the fundamental theorem of natural selection of any use?

Evolution; international journal of organic evolution·2026
Same author

Functional and evolutionary diversification of luciferase genes in Metridia lucens Boeck 1865.

Scientific reports·2026
Same author

The rights and wrongs of rescaling in population genetics simulations.

ArXiv·2026
Same author

Functional and evolutionary diversification of luciferase genes in Metridia lucens.

Research square·2025

Area of Science:

  • Evolutionary biology
  • Population genetics
  • Genomics

Background:

  • Closely related species often share ancestral polymorphisms.
  • Using distant relatives as outgroups aids in detecting these polymorphisms.

Purpose of the Study:

  • To present an improved method for estimating the fraction of ancestral polymorphisms.
  • To derive formulae for fixation proportions from ancestral polymorphisms and new mutations.

Main Methods:

  • Developed a novel statistical method for ancestral polymorphism estimation.
  • Applied the method to genetic data from Drosophila pseudoobscura and D. miranda.
  • Derived mathematical formulae for fixation proportions.

Main Results:

Related Experiment Videos

  • The new method enhances the accuracy of ancestral polymorphism fraction estimates.
  • Formulae were derived for the proportion of fixations originating from ancestral polymorphisms versus new mutations.
  • Demonstrated utility with Drosophila species data.

    • Conclusions:

    • The developed method improves the detection and estimation of ancestral polymorphisms.
    • The derived formulae are valuable for selection tests using polymorphism data.
    • Findings contribute to understanding evolutionary processes in closely related species.