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Dumping syndrome: pathophysiology and treatment.

Andrew Ukleja1

  • 1Department of Gasteroenterology, Cleveland Clinic Florida, Weston, FL 33331, USA. uklejaa@ccf.org

Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
|October 7, 2005
PubMed
Summary

Dumping syndrome, a complication of gastric surgery affecting 10% of patients, involves altered stomach function and gastrointestinal hormone responses. Management includes diet, medication, and surgery, with refractory cases posing challenges.

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Area of Science:

  • Gastroenterology
  • Surgical Complications
  • Physiology

Background:

  • Gastric surgery can lead to significant dumping syndrome in about 10% of patients.
  • Dumping syndrome arises from altered stomach motor functions, affecting reservoir and transport.
  • Gastrointestinal hormones are key mediators in the response to surgical resection.

Purpose of the Study:

  • To review the mechanisms of dumping syndrome.
  • To highlight current therapeutic strategies for dumping syndrome.
  • To address the challenges in managing refractory cases.

Main Methods:

  • Literature review of mechanisms and therapies for dumping syndrome.
  • Analysis of the role of gastrointestinal hormones.
  • Evaluation of treatment options including diet, medication, and surgical revision.

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Main Results:

  • Dumping syndrome is linked to motor function alterations post-gastric surgery.
  • Gastrointestinal hormones play a crucial role in mediating symptoms.
  • Conservative therapies may fail, leading to poor nutritional status.

Conclusions:

  • Refractory dumping syndrome management is challenging.
  • A comprehensive understanding of mechanisms and therapies is essential.
  • This review provides insights into current knowledge and treatment approaches.