Prediction of endocrine stress reactions by means of personality variables

The study examined the predictability of endocrine stress indicators on the basis of personality measures. The subjects were 83 computer operators (63 men, 20 women; mean age 28 years) who by means of an experimental situation were confronted with a mild stressor (a cognitive two-channel task with a high information load). Using scores on personality questionnaires (comprising scales for defense mechanisms, neuroticism, and 2 achievement motivation variables), subjects were classified into extreme groups of stress-resistant (17 subjects) versus nonstress-resistant (13 subjects). Immediately after the experiment blood samples were taken to assay the norepinephrine metabolites plasma-free 3-methoxy-4-hydroxy-phenylglycol (MHPG) and MHPG sulfate (MHPG.SO4), which formed the dependent variables. Personality measures and endocrine stress indicators were until the final analysis of the data kept apart by a double-blind strategy. A significant difference was noted in the MHPG level between the stress-resistant and the nonstress-resistant group. The value and applicability of these results for stress prevention is discussed.