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Transient global amnesia in a patient with high and persistent levels of antiphospholipid antibodies

Norberto Ortego-Centeno1, José Luis Callejas-Rubio, Miguel Guerrero Fernández

  • 1Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Clínico San Cecilio, Dr. Oloriz s/n, 18012 Granada, Spain. nortego@telefonica.net

Clinical Rheumatology
|October 7, 2005
PubMed

Insights

Antiphospholipid antibodies, including anticardiolipin antibodies (ACA) and lupus anticoagulant (LA), may be linked to transient global amnesia (TGA). Further research is needed to understand this association and its implications for antiphospholipid syndrome patients.

Area of Science:

  • Neurology
  • Immunology

Background:

  • Antiphospholipid syndrome (APS) is associated with cerebrovascular events like ischemic stroke, often linked to anticardiolipin antibodies (ACA) and lupus anticoagulant (LA).
  • The precise relationship between these antibodies and various neurological disorders in APS patients remains unclear.
  • Transient global amnesia (TGA) is a neurological disturbance characterized by temporary memory loss, with an unknown pathophysiology.

Observation:

  • This report details a case of TGA in a patient with persistently high levels of ACA and LA.
  • The patient experienced a sudden inability to form new memories, typical of TGA.

Findings:

  • The study suggests a potential association between TGA and the presence of ACA and LA.
  • A higher prevalence of TGA may exist in patients with antiphospholipid syndrome compared to the general population.

Implications:

  • Investigating ACA and LA in TGA patients could reveal new insights into the pathogenesis of neurological diseases associated with antiphospholipid antibodies.
  • This finding may prompt further research into the role of antiphospholipid antibodies in non-stroke neurological manifestations of APS.

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