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[Prolactin (PRL), thyrotropin (TSH), free thyroid hormones (fT4), (fT3) and testosterone (TTE) level in men with

Ewa Opalińska-Ciszek1, Stanisław Niemczyk, Joanna Matuszkiewicz-Rowińska

  • 1Oddzial Chorób Wewnetrznych ze Stacja Dializ Szpitala Powiatowego w Wolominie.

Polskie Archiwum Medycyny Wewnetrznej
|October 8, 2005
PubMed

Insights

Hormonal imbalances, including elevated prolactin and low testosterone, are common in men with chronic heart failure (CHF). These endocrine disorders worsen with increased CHF severity, impacting prognosis and treatment strategies.

Area of Science:

  • Endocrinology
  • Cardiology
  • Internal Medicine

Context:

  • Chronic heart failure (CHF) affects multiple endocrine glands beyond the renin-angiotensin-aldosterone system.
  • The extent of hormonal disturbances correlates with CHF severity, but its impact on prognosis and treatment remains unclear.

Purpose:

  • To determine the frequency of hormonal secretion disturbances in male CHF patients (NYHA class II-IV, LVEF <35%).
  • To assess the relationship between hormone levels (prolactin, testosterone, thyroid hormones) and the clinical severity of CHF.

Summary:

  • 52% of male CHF patients exhibited hormonal disturbances, with increased frequency in higher NYHA classes (III/IV).
  • Elevated prolactin and decreased testosterone were the most common findings.
  • No significant correlation was found between hormonal changes and left ventricular ejection fraction.

Impact:

  • CHF is frequently associated with endocrine dysfunction, with higher prevalence in advanced stages.
  • Findings highlight the need to consider hormonal assessment in managing male CHF patients.
  • Understanding these endocrine changes may inform therapeutic strategies and improve patient outcomes.

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