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Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells
Published on: February 2, 2024
[Insulin-like growth factor and interacting proteins]
Aleksandra Obrepalska-Steplowska1, Lukasz Durzyński, Anna Goździcka-Józefiak
1Interdepartmental Laboratory of Molecular Biology, Plant Protection Institute, 20 Miczurina St., 60-318 Poznan, Poland. ao.steplowska@ior.poznan.pl
Abstract:
Insulin-like growth factor - IGF-I is a small, 70 aminoacid mitogenic peptide, contributing to processes of growing, cancerogenesis, apoptosis, wound healing and many others. It constitutes so called 'somatotropic axis GH-IGF', composed of many other components. This axis is responsible for regulation of metabolic processes, and its proper functioning conditions organism's homeostasis. Presented work describes concise review of publications concerning IGF-I structure, function, expression and proteins affecting its activity, synthesis and circulation.
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