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Updated: Jul 31, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Direct atom-efficient esterification between carboxylic acids and alcohols catalyzed by amphoteric, water-tolerant
Chien-Tien Chen1, Yogesh S Munot
1Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 11650. chefv043@ntnu.edu.tw
Abstract:
A diverse array of oxometallic species were examined as catalysts for a test direct condensation of benzoic acid and 2-phenylethanol in 1:1 stoichiometry. Besides group IVB MOCl2-xH2O and TiOX2-xH2O, group VB VOCl2-xTHF and group IVB TiO(acac)2 were found to be the most efficient and water-tolerant catalysts for the test reaction. The new neutral catalytic protocol with the optimal TiO(acac)2 tolerates many stereo/electronic structural variations in both (di)acid (1 degree -3 degrees alkyl and aryl) and (di)alcohol (1 degree, 2 degrees alkyl, and aryl) components with high chemoselectivity.
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