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Related Experiment Videos

Discovering hidden viral piracy.

Eddo Kim1, Yossef Kliger

  • 1Compugen Ltd Tel Aviv 69512, Israel.

Bioinformatics (Oxford, England)
|October 8, 2005
PubMed
Summary
This summary is machine-generated.

Researchers discovered over 900 hidden viral-human protein homologs using a novel method. These homologous proteins, often missed due to low similarity, may be key to immune modulation and therapeutic development.

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Area of Science:

  • Virology
  • Immunology
  • Bioinformatics

Background:

  • Viruses and anti-inflammatory drug developers target immune-modulating proteins.
  • Large double-stranded DNA viruses pirate host proteins to evade immune defenses, suggesting therapeutic potential.
  • Many viral piracy events remain undiscovered due to sequence divergence.

Purpose of the Study:

  • To develop a computational method for identifying highly diverged viral/human homologous proteins.
  • To uncover previously hidden homologous proteins masked by low-similarity alignment hits.
  • To explore the therapeutic potential of newly identified homologous proteins in immune modulation.

Main Methods:

  • Developed a novel computational method to assess viral/human homologs.
  • Implemented a filtering strategy to enhance the proportion of true homologous proteins.

Related Experiment Videos

  • Analyzed low-similarity alignment hits typically ignored in sequence comparisons.

    • Main Results:

    • Identified at least 917 highly diverged viral/human homologous proteins.
    • Demonstrated that many homologous proteins are hidden in low-similarity alignment hits.
    • Showcased the utility of these homologs for functional annotation and identifying immune-modulating candidates.

    Conclusions:

    • A significant number of highly diverged viral/human homologs exist, previously undetected.
    • These newly identified homologous proteins offer potential for functional annotation and therapeutic applications.
    • The developed method enhances the discovery of evolutionarily related proteins with immune-modulating functions.