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Glucose abnormalities and heart failure predict poor prognosis in the population-based Reykjavík Study

Inga S Thrainsdottir1, Thor Aspelund, Thordur Hardarson

  • 1Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden. inga.thrainsdottir@medks.ki.se

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
|October 8, 2005
PubMed

Insights

Heart failure and abnormal glucose regulation, including diabetes, increase cardiovascular risks. Their combination significantly raises mortality, particularly with ischemic heart disease.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Cardiovascular disease risk escalates with rising blood glucose, even below diabetic thresholds.
  • A link between heart failure and abnormal glucose regulation, including impaired glucose tolerance, was observed in the Reykjavík Study.

Purpose of the Study:

  • To investigate the prognosis of individuals with co-existing glucose abnormalities and heart failure.
  • To determine if this combination exacerbates adverse health outcomes.

Main Methods:

  • A prospective, population-based study involving 19,381 participants.
  • Participants were categorized by glucose regulation and heart failure status.
  • Mortality and morbidity risks were analyzed, adjusted for cardiovascular risk factors and ischemic heart disease.

Main Results:

  • Mortality risk was lowest in the reference group and highest in those with both glucose abnormality and heart failure.
  • Abnormal glucose regulation increased mortality risk, but less than diabetes.
  • The highest risk for new myocardial infarction was observed in participants with diabetes, especially when combined with heart failure.

Conclusions:

  • Both heart failure and glucose abnormalities independently elevate morbidity and mortality risks.
  • The presence of ischemic heart disease did not further worsen the prognosis when combined with glucose abnormality and heart failure.
Abstract

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