[Effect of the central noradrenergic system on carotid sinus reflex in rats]

In order to study the effect of central noradrenergic system on the regulation of mean arterial pressure (MAP) by intracarotid sinus pressure (ISP), ISP-MAP relationship curves were constructed using isolated carotid sinus under the condition of injection of 6-OHDA (200 micrograms) into lateral ventricle or cauterization of locus coeruleus (LC) and compared with that obtained under the condition of control. All ISP-MAP curves can be fitted by a logistic functional plot whose characteristics can be defined by two parameters, i.e. coordinates of the inversion point of the slope of the curve and the MAP range related to the rate of change of slope factor with which carotid sinus pressure exerts its control. The results were as follows: After injection of 6-OHDA, the rate of change of the slope of the ISP-MAP curve is considerably slower than that of the normal control, thus showing a much compressed range of MAP by ISP, while the abscissa (i.e. position of ISP) of the slope inversion point of the curve shows practically no change. In comparison with the control, cauterization of LC causes a similar but less striking change of ISP-MAP curve than that of 6-OHDA injection experiment. All such differences were illustrated in Fig. 3. The above results indicated that the central noradrenergic system facilitates carotid sinus reflex and LC plays a dominant role.