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Association between interleukin-1beta-511C/T polymorphism and reflux esophagitis in Japan

Atsushi Muramatsu1, Takeshi Azuma, Tomoyuki Okuda

  • 1Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan.

Journal of Gastroenterology
|October 8, 2005
PubMed
Summary

Interleukin-1beta (IL-1beta) gene polymorphisms, specifically the IL-1beta-511T allele, are linked to an increased risk of reflux esophagitis. This genetic association suggests a role in hyperacidity and gastric acid secretion differences.

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