Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progestogen only contraception and endometrial break through bleeding.

Oliver P Milling Smith1, Hilary O D Critchley

  • 1Department of Reproductive and Developmental Sciences, The University of Edinburgh, Edinburgh, UK.

Angiogenesis
|October 8, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter to the editor: Anovulatory bleeding and the spectrum of bleeding disorders: Understanding heavy menstrual bleeding in adolescents.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same author

Appraisal of international, patient-facing resources on heavy menstrual bleeding.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same author

The potential bidirectional relationship between long COVID and menstruation.

Nature communications·2025
Same author

Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.

NAR molecular medicine·2025
Same author

Ending the taboo on periods and period problems.

Nature medicine·2025
Same author

Feasibility study of the application of magnetic resonance elastography to diagnose uterine adenomyosis.

F&S science·2025

Progestogen-only contraceptives (POCs) are effective but cause breakthrough bleeding (BTB). This review explores how POCs affect the endometrium and lead to BTB, aiding in understanding and management.

Area of Science:

  • Reproductive endocrinology
  • Gynecology
  • Pharmacology

Background:

  • Progestogen-only contraceptives (POCs) are widely used for fertility regulation.
  • Breakthrough bleeding (BTB) is a common side effect of POCs, leading to treatment discontinuation.
  • Endometrial vascular fragility is implicated in BTB, but mechanisms linking POCs to this are not fully understood.

Purpose of the Study:

  • To review commonly used POCs.
  • To describe their effects on endometrial morphology.
  • To explore molecular and cellular mechanisms underlying unscheduled bleeding caused by POCs.

Main Methods:

  • Literature review of studies on progestogen-only contraceptives.
  • Analysis of endometrial changes associated with POC use.

Related Experiment Videos

  • Examination of molecular and cellular pathways involved in BTB.

    • Main Results:

    • POCs alter endometrial morphology.
    • Specific molecular and cellular mechanisms contribute to increased endometrial vascular fragility.
    • These changes are linked to the occurrence of unscheduled bleeding.

    Conclusions:

    • Understanding the mechanisms of BTB induced by POCs is crucial for improving contraceptive options.
    • Further research into the endometrial-vasculature interaction can lead to better management strategies for BTB.
    • This review consolidates current knowledge on POCs, endometrial effects, and BTB mechanisms.