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Updated: Aug 15, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

[Diagnostics and therapy for invasive fungal infections in an intensive care unit]

S Koch1, H Haefner, F Huenger

  • 1Zentralbereich für Krankenhaushygiene und Infektiologie, Universitätsklinikum Aachen, RWTH Aachen. sukoch@ukaachen.de

Der Anaesthesist
|October 8, 2005
PubMed

Insights

Invasive fungal infections like candidemia and aspergillosis are rising and challenging to diagnose. This review covers key diagnostic and therapeutic options for critical care settings.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Mycology

Context:

  • Invasive fungal infections (IFIs) have increasing incidence and high mortality.
  • Candidemia and invasive pulmonary aspergillosis are prevalent in critical care.
  • Risk factors include broad-spectrum antibiotics, ICU stays, and GI surgery.

Purpose:

  • To review diagnostic and therapeutic strategies for severe Candida infections and invasive aspergillosis.
  • To provide clinicians with knowledge on indications and limitations of antifungal agents.
  • To address challenges in diagnosing invasive fungal infections.

Summary:

  • Focuses on diagnostic challenges and therapeutic options for candidemia and invasive aspergillosis.
  • Details antifungal agents: fluconazole, amphotericin B (conventional and liposomal), caspofungin, and voriconazole.
  • Emphasizes the need for precise knowledge for rational and cost-effective treatment.

Impact:

  • Aims to improve clinical decision-making in managing severe fungal infections.
  • Contributes to better patient outcomes in critical care by optimizing antifungal therapy.
  • Highlights the importance of understanding specific indications for various antifungal drugs.

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