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Gastric carcinoids: a temporal increase with proton pump introduction.
N Hodgson1, L G Koniaris, A S Livingstone
1Dewitt Daughtry Department of Surgery and the Sylvester Comprehensive Cancer Center, University of Miami, 3550 Sylvester Comprehensive Cancer Center (310T), 1475 NW 12th Avenue, Miami, FL 33136, USA.
Surgical Endoscopy
|October 8, 2005
Summary
Gastric carcinoid tumors show a significant increase in incidence, rising eight- to ninefold over two decades. This trend may be linked to increased proton pump inhibitor use and improved endoscopic detection methods.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Recent reports indicate a rising incidence of gastric carcinoids.
- This study evaluates the incidence pattern of gastric carcinoids in two large population-based cancer registries.
Purpose of the Study:
- To evaluate the incidence pattern of gastric carcinoids.
- To analyze trends in gastric carcinoid incidence over a 20-year period.
Main Methods:
- Utilized data from the Florida Cancer Data System (FCDS) and the Surveillance, Epidemiology, and End Results (SEER) program.
- Analyzed all identified gastric carcinoid cases from January 1981 to December 2000.
- Calculated descriptive statistics and age-adjusted incidence rates.
Main Results:
- Identified 326 (FCDS) and 594 (SEER) cases of invasive gastric carcinoid.
- Observed a significant increase in age-adjusted incidence rates, from 0.04 to 0.18 per 100,000 by 2000.
- Reported an annual percentage increase of 8.17% (FCDS) and 9.17% (SEER), contrasting with a decrease in overall gastric cancer incidence.
Conclusions:
- Documented a statistically significant eight- to ninefold increase in gastric carcinoid incidence.
- Correlated the temporal increase with the widespread use of proton pump inhibitors and improved endoscopic detection.
- Recommended further epidemiologic studies to investigate these trends.