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Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia
Matthew P Doogue1, Evan J Begg, Paul Bridgman
1Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand. matthewd@cdhb.govt.nz
Abstract:
We report a case of a severe hypersensitivity syndrome reaction to clopidogrel that resolved with dechallenge and recurred on rechallenge. The reaction included neutropenia, rash, fever, tachycardia, nausea, and vomiting. This presentation is very similar to the frequently reported hypersensitivity syndrome reactions to the structurally similar drug ticlopidine and is very similar to a case involving clopidogrel reported previously in this Journal. We could find no other reports of similar cases related to clopidogrel.
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