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Invasive fungal infections in living unrelated renal transplantation

A M Alkhunaizi1, A A Amir, J A Al-Tawfiq

  • 1Dhahran Health Center Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia. ahmed.khunaizi@aramco.com

Transplantation Proceedings
|October 11, 2005
PubMed

Insights

Paid living unrelated renal transplantation is common in developing nations. This practice carries a high risk of severe invasive fungal infections, leading to significant morbidity and mortality.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Renal transplantation from paid, unrelated donors is prevalent in many developing countries.
  • This practice is associated with significant medical and social challenges.
  • Invasive fungal infections represent a major feared complication in this context.

Observation:

  • This report details three cases of living unrelated renal transplantation (LURTX) complicated by invasive fungal infections.
  • Patients presented with disseminated mucormycosis, invasive aspergillosis (IA), and central nervous system (CNS) infection caused by Ramichloridium mackenziei.

Findings:

  • Two of the three patients succumbed to their infections within months of diagnosis.
  • The surviving patient experienced hemiplegia and remains debilitated.

Implications:

  • Living unrelated renal transplantation, particularly when involving payment, poses substantial risks of life-threatening fungal infections.
  • Healthcare providers should be vigilant for these infections in patients undergoing LURTX.
  • The findings highlight the critical need for improved screening, management, and ethical considerations in organ transplantation practices in resource-limited settings.

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