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Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study.

Philipp R Rau1, Johann Sellner, Sabine Heiland

  • 1University of Heidelberg, Department of Neurology, INF 400-Kopfklinik, D-69120 Heidelberg, Germany. philipp.rau@gmail.com

Life Sciences
|October 11, 2005
PubMed
Summary
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Apparent diffusion coefficients (ADCs) in the aging mouse brain remain largely constant. Diffusion-weighted imaging (DWI) showed minimal age-related changes, indicating stable brain diffusion throughout life.

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Biomedical Engineering

Background:

  • Diffusion-weighted imaging (DWI) is crucial for diagnosing neurological conditions.
  • The impact of aging on brain diffusion parameters requires further investigation.
  • Establishing age-related reference values for mouse brain diffusion is essential for research.

Purpose of the Study:

  • To determine if absolute apparent diffusion coefficients (ADCs) in the normal mouse brain change with age.
  • To establish age-specific reference values for mouse brain ADCs.
  • To investigate the relationship between brain diffusion and aging in mice.

Main Methods:

  • 41 healthy mice of varying ages were scanned using T2-weighted imaging and DWI.
  • Apparent diffusion coefficients (ADCs) were calculated using voxel-by-voxel frequency histograms and region-of-interest (ROI) measurements.

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  • ADC values were analyzed and correlated with the age of the mice.

    • Main Results:

    • Mean whole brain ADCs showed a non-significant trend towards lower values in older mice.
    • No significant correlation was found between age and whole brain ADCs across different age groups.
    • Region-of-interest analyses in the parietal lobe, striatum, and temporal lobe also revealed minimal age-related diffusion changes.

    Conclusions:

    • Absolute apparent diffusion coefficients (ADCs) remain relatively constant in the aging mouse brain.
    • Aging has a minimal impact on brain diffusion as measured by DWI.
    • The study provides reference ADC values for normal aging mouse brains, useful for future research.