A QSAR study on influenza neuraminidase inhibitors
Rajeshwar P Verma1, Corwin Hansch
1Department of Chemistry, Pomona College, Claremont, CA 91711, USA.
Abstract:
Influenza is a major respiratory infection associated with significant morbidity in the general population and mortality in elderly and high-risk patients. It is an RNA virus that contains two major surface glycoproteins, neuraminidase and hemagglutinin. These proteins are essential for infection. Neuraminidase has been found to be a potential target to control influenza virus. In this paper, we have developed 17 quantitative structure-activity relationships (QSAR) for different sets of compounds to understand chemical-biological interactions governing their activities toward influenza neuraminidase.
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