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Updated: Aug 15, 2026

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Aromatase and regulation of bone remodeling
Claude Ribot1, Florence Trémollieres, Jean-Michel Pouillés
1UF Ménopause et Maladies Osseuse Métaboliques, Hôpital Paule de Viguier, jean Poulhes, Beforecty, Toulouse, France. ribot.c@chu-toulouse.fr
Abstract:
Estrogens play a key role in regulating bone mineralization. Bone tissue expresses the enzymes that metabolize estrogens, as well as the alpha and beta receptors that mediate responses to estrogens. After the menopause, estrogen secretion by the ovaries is promptly replaced by production within tissues, which occurs chiefly via aromatization of adrenal steroids. Therefore, aromatase activity is a major determinant of estrogen activity in postmenopausal women. Studies are beginning to shed light on the mechanisms by which aromatase activity influences bone remodeling.
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