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Updated: Aug 15, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Published on: June 6, 2017
Cell cycle: how cyclin E got its groove back
Markus Welcker1, Bruce Clurman
1Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Abstract:
CDK1 has long been known to orchestrate the passage of mammalian cells into and through mitosis. Recent work revisits the idea that CDK1, in conjunction with cyclin E, participates in S-phase entry as well. The new results shed light on a recent cell-cycle mystery, and provide another dramatic example of apparent functional redundancy among cyclins and cyclin-dependent kinases.
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