Sperm DNA damage assessment: a test whose time has come
Related Experiment Video
Updated: Aug 15, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
Ashok Agarwal1, Shyam S R Allamaneni
1Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. agarwaa@ccf.org
Abstract:
Multiple techniques have been developed to measure the amount of sperm DNA damage in an effort to identify more objective parameters for evaluation of infertile men. We now have evidence to support that integrity of sperm DNA influences a couple's fertility and helps predict the chances of pregnancy and its successful outcome. The available tests of sperm DNA damage require additional large-scale clinical trials before their integration into routine clinical practice.
Related Concept Videos
Spermatogenesis
DNA Damage can Stall the Cell Cycle