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Related Experiment Videos

Bacterial detection of platelets: current problems and possible resolutions.

Morris A Blajchman1, Erik A M Beckers, Ebbe Dickmeiss

  • 1McMaster University and Canadian Blood Services, Hamilton, Ontario, Canada. blajchma@mcmaster.ca

Transfusion Medicine Reviews
|October 11, 2005
PubMed
Summary

Bacterial sepsis is a major risk in blood transfusions. Current bacterial screening of platelets may not prevent all infections, leading experts to recommend pathogen inactivation for enhanced blood product safety.

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Infectious Disease Prevention

Background:

  • Bacterial sepsis presents the most significant transfusion-transmitted disease risk to recipients.
  • Bacterial contamination affects approximately 1 in 3,000 blood units, leading to sepsis in 1 in 25,000 platelet and 1 in 250,000 red blood cell transfusions.

Purpose of the Study:

  • To summarize expert experiences and recommendations on routine bacterial detection in platelet products.
  • To evaluate the effectiveness of current bacterial screening technologies and explore alternative safety measures.

Main Methods:

  • A roundtable meeting of experts at the XXVIII Annual Congress of the International Society of Blood Transfusion.
  • Review of data on bacterial screening technology and transfusion-associated sepsis case reports.

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Main Results:

  • Current bacterial screening can identify high-level contamination but may not prevent all infections, as units can become positive upon longer storage.
  • Case reports highlighted limitations of routine screening for platelet products.

Conclusions:

  • Bacterial screening alone is insufficient to eliminate transfusion-transmitted bacterial infections.
  • Pathogen inactivation technologies offer a more reliable approach to reducing transfusion-associated sepsis risk.
  • Experts recommended considering pathogen inactivation systems for blood products.