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Updated: Jan 1, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Membrane receptors mediating thyroid hormone action.

Paul J Davis1, Faith B Davis, Vivian Cody

  • 1Ordway Research Institute Inc., Albany, NY 12208, USA. pdavis@ordwayresearch.org

Trends in Endocrinology and Metabolism: TEM
|October 11, 2005
PubMed
Summary
This summary is machine-generated.

Thyroid hormone acts via a cell surface receptor on integrin alphaVbeta3, activating signaling pathways. This discovery allows for targeted hormone modifications to control specific cellular responses like tumor growth.

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Area of Science:

  • Endocrinology
  • Cell Biology
  • Molecular Signaling

Background:

  • Thyroid hormone traditionally acts via nuclear receptors.
  • A novel cell surface receptor for thyroid hormone has been identified on integrin alphaVbeta3.
  • This receptor initiates rapid signaling cascades.

Purpose of the Study:

  • To investigate the signaling pathways activated by the thyroid hormone cell surface receptor.
  • To explore the implications of this receptor for therapeutic applications.
  • To demonstrate the feasibility of modifying thyroid hormone to target cell surface actions.

Main Methods:

  • Utilized human cell lines to study thyroid hormone receptor interactions.
  • Investigated the activation of the mitogen-activated protein kinase (MAPK) signaling pathway.
  • Analyzed downstream effects including ion pump stimulation and nuclear events.

Main Results:

  • Identified integrin alphaVbeta3 as a thyroid hormone cell surface receptor.
  • Demonstrated MAPK pathway activation by this receptor.
  • Observed MAPK-dependent stimulation of ion pumps and nuclear events, including receptor phosphorylation and coactivator recruitment.
  • Linked these events to thyroid hormone-induced angiogenesis and tumor cell growth.

Conclusions:

  • Thyroid hormone exerts rapid, non-genomic effects through cell surface integrin alphaVbeta3.
  • This receptor mediates crucial cellular processes like angiogenesis and tumor growth.
  • Structural modification of thyroid hormone offers a strategy to selectively modulate cell surface receptor activity, potentially leading to novel therapeutic interventions.