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Updated: Aug 15, 2026

Culturing and Measuring Fetal and Newborn Murine Long Bones
06:58

Culturing and Measuring Fetal and Newborn Murine Long Bones

Published on: April 26, 2019

High bone turnover of type I collagen depends on fetal growth

Kazutoshi Nakano1, Toshiyuki Iwamatsu, Cong Mei Wang

  • 1Department of Pediatrics, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. knakano@ped.twmu.ac.jp

Bone
|October 11, 2005
PubMed

Insights

Bone turnover markers, carboxy-terminal propeptide of type I procollagen (PICP) and pyridinoline cross-linked telopeptide domain of type I collagen (ICTP), are high in newborns and decrease with fetal growth. Fetal osteoblasts drive proliferation, but maturation factors need further study.

Area of Science:

  • Neonatal Physiology
  • Skeletal Biology
  • Endocrinology

Background:

  • Bone metabolism in newborns is not fully understood.
  • Preterm and term newborns exhibit distinct developmental trajectories.

Purpose of the Study:

  • To elucidate bone metabolic processes in preterm and term newborns.
  • To investigate the relationship between fetal growth and bone turnover markers.

Main Methods:

  • Collected umbilical cord blood from 74 newborns (27-42 gestational weeks).
  • Measured bone metabolic markers: PICP, ICTP, ALP, BAP.
  • Assessed hormones: CT, E2, PTH, IGF-I.
  • Performed cross-sectional regression analyses with fetal growth parameters (GWs, BW, BH, HC).

Main Results:

  • PICP and ICTP were significantly elevated and decreased with increasing gestational age, birth weight, height, and head circumference.
  • BAP and ALP levels did not change significantly with fetal growth.
  • E2 and CT correlated positively with calcium but not with bone markers.

Conclusions:

  • Bone formation and resorption are highly active in fetuses, dependent on fetal growth.
  • Fetal osteoblasts primarily influence the proliferation phase of bone development.
  • Further research is needed to identify factors contributing to high fetal bone turnover.

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