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Parenteral nutrition-associated hepatotoxicity
Andrea Fulford1, James S Scolapio, Jaime Aranda-Michel
1St. Luke's Hospital, Department of Clinical Nutrition, Mayo Clinic Jacksonville, Florida, USA.
Summary
Parenteral nutrition can cause liver damage (hepatotoxicity). This review examines the causes, diagnosis, and treatments for this condition, highlighting the need for more research.
Area of Science:
- Hepatology
- Clinical Nutrition
- Gastroenterology
Background:
- Parenteral nutrition (PN) is linked to various hepatobiliary complications.
- PN-induced hepatotoxicity is a significant concern in patients receiving nutritional support.
Purpose of the Study:
- To review the current literature on parenteral nutrition-induced hepatotoxicity.
- To synthesize information on the etiology, pathogenesis, diagnosis, prevention, and treatment of PN-associated liver injury.
Main Methods:
- A comprehensive literature search was conducted.
- Articles published between 1999 and 2003 were reviewed.
Main Results:
- Identified suspected etiologies and pathogenesis of PN-associated hepatotoxicity.
- Summarized commonly used diagnostic tests and procedures.
- Outlined current prevention and treatment strategies.
Conclusions:
- Despite advances, significant knowledge gaps remain regarding PN-induced hepatobiliary complications.
- Further research, especially in human subjects, is crucial for understanding and managing PN-associated hepatotoxicity.
- Clinical practitioners are encouraged to contribute to ongoing research efforts.