Related Experiment Video
Updated: Aug 15, 2026
A Single Cell Dissociation Approach for Molecular Analysis of Urinary Bladder in the Mouse Following Spinal Cord Injury
Published on: June 17, 2020
Free insulin-like growth factor-1 levels in bladder growth following spinal cord injury experimentally
T Ahmet Serel1, Eda Uysal, Süleyman Kutluhan
1Department of Urology, Suleyman Demirel University, School of Medicine, Isparta, and Ankara Numune Hospital, Turkey. aserel@med.sdu.edu.tr
Introduction:
To determine the levels of spinal cord injury (SCI) on free insulin-like growth factor-1 (IGF-1) content in the bladder and the possible role of free IGF-1 in growth in hypertrophic bladders in an experimental model.
Materials And Methods:
The contents of free IGF-1 and protein in paraplegic and non-paraplegic rats which was induced experimentally by SCI were measured. The wet weights of the bladders were also determined. The results gained were compared.
Results:
The mean bladder free IGF-1 level in paraplegic rats was significantly higher than the corresponding bladder free IGF-1 level in sham-operated bladder (p<0.05). Mean wet weight bladder in paraplegic rats was significantly higher than the sham-operated rats (p<0.05). Paraplegic bladder had a significantly higher mean protein content than the sham-operated bladder (p<0.05). Serum free IGF-1 levels in the two groups were not different.
Conclusion:
Our pilot study reveals that free IGF-1 may be effective in SCI.
