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Related Experiment Videos

Small intestinal manometry in patients with systemic sclerosis.

Kristina Sjölund1, Izabella Bartosik, Greger Lindberg

  • 1Department of Internal Medicine, Lund University Hospital, Sweden. kristina.sjolund@med.lu.se

European Journal of Gastroenterology & Hepatology
|October 11, 2005
PubMed
Summary

Systemic sclerosis frequently causes intestinal pseudo-obstruction, indicated by abnormal small intestinal manometry. This motility disorder, potentially due to neuropathy and myopathy, was observed in 80% of patients and was not linked to peptide levels.

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Area of Science:

  • Gastroenterology
  • Rheumatology
  • Clinical Physiology

Background:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease.
  • Gastrointestinal (GI) dysmotility is a common complication of SSc.
  • Small intestinal involvement in SSc requires further characterization.

Purpose of the Study:

  • To investigate the frequency and severity of small intestinal dysmotility in SSc patients using manometry.
  • To correlate manometric findings with clinical symptoms, radiological findings, and intestinal regulatory peptides.
  • To assess the underlying mechanisms of SSc-related small intestinal dysfunction.

Main Methods:

  • Stationary antroduodeno-jejunal manometry performed on 10 SSc patients and 10 healthy controls.
  • Measurements taken during fasting, post-meal, and after octreotide administration.

Related Experiment Videos

  • Plasma levels of motilin, peptide YY, cholecystokinin, and somatostatin analyzed.

    • Main Results:

    • Eight out of 10 SSc patients exhibited abnormal manometry, indicative of intestinal pseudo-obstruction.
    • Reduced mean contractile amplitudes and altered activity complexes observed in SSc patients compared to controls.
    • No significant difference in plasma peptide levels between SSc patients and controls; no small intestinal dilatation noted on radiography.

    Conclusions:

    • Manometric criteria for intestinal pseudo-obstruction were met in 80% of SSc patients.
    • The motility pattern suggests a combination of neuropathy and myopathy.
    • Release of motility-regulating peptides remains unaffected in SSc patients with GI dysmotility.