Related Experiment Video
Updated: Aug 4, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Low grade multiple myeloma that presented as a labial swelling -- a case report
S Ariyaratnam1, C Sweet, J Duxbury
11S. Ariyaratnam, Specialist in Oral Medicine and Surgical Dentistry, Unit of Oral Medicine, University Dental Hospital of Manchester, Manchester, M15 6FH, UK. senathirajah.ariyaratnam@man.ac.uk
British Dental Journal
|October 11, 2005
Summary
Multiple myeloma, a plasma cell cancer, can cause amyloidosis. This case highlights rare oral arterial amyloidosis as an early sign of multiple myeloma.
Area of Science:
- Oncology
- Pathology
- Nephrology
Background:
- Multiple myeloma is a plasma cell malignancy affecting bone marrow.
- It often involves monoclonal immunoglobulin accumulation and can lead to renal failure and bone destruction.
- Amyloidosis is a known complication, with macroglossia being a common oral manifestation.
Observation:
- This report details a unique case of amyloid deposition surrounding an artery in the oral cavity.
- The initial presentation was an unassuming lower labial swelling.
- This finding was not previously described in the context of multiple myeloma-associated amyloidosis.
Findings:
- Amyloid deposition was identified surrounding an artery in the lower lip.
- Subsequent investigations revealed the underlying cause to be multiple myeloma.
- This represents a novel oral manifestation of amyloidosis secondary to multiple myeloma.
Implications:
- Oral amyloidosis, particularly perivascular deposition, may serve as an early diagnostic indicator for multiple myeloma.
- Recognizing rare oral signs can improve early detection and management of systemic diseases like multiple myeloma.
- This case expands the spectrum of oral manifestations associated with multiple myeloma and its complications.
