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[Correlation between fibrinogen polymorphisms and the type of cerebral infarction]
Shu-juan Wang1, Xiao-dong Yuan, Jie Gao
1Department of Neurology, Kailuan Hospital, Tangshan, Hebei, PR China.
Objective:
To study the association of beta-fibrinogen(Fg) gene -148 C/T and 448 G/A polymorphisms, plasma Fg concentration, molecular reactivity and the type of cerebral infarction.
Methods:
Gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The plasma Fg concentration and the molecular reactivity were also determined.
Results:
The Fg concentration in MCI patients with T -148 allele was higher than that in PCI patients and controls. The MCI patients with A448 allele had higher Fg concentration, FMPV and FMPV/Amax when compared with controls, and had higher FMPV/Amax when compared with PCI patients.
Conclusion:
FgB beta -148 and 448 mutational genotypes have impact on Fg concentrationì and therefore increase the risk of MCI.
