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Updated: May 23, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
[Polymorphism of HLA-A,-B and DRB1 in Han population of Shanxi province]
Tao Lan1, De-mei Zhang, Gui-qin Wang
1Department of Pediatrics, People's Hospital of Shanxi Province, Taiyuan, Shanxi, PR China. Lantao111@sina.com
Objective:
To investigate the polymorphism of HLA-A, -B, -DRB1 genes in Han population in Shanxi of China.
Methods:
Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to identify the polymorphism of HLA-A, -B, -DRB1 genes of 7440 healthy and unrelated individuals of Han population in Shanxi, and the gene frequency distribution of HLA-A, -B, -DRB1 genes in population was compared with the results from other populations.
Results:
Eighteen HLA-A, forty HLA-B and thirteen HLA-DRB1 alleles were found. The frequencies of A*02, A*24, A*11, A*01, A*03, B*13, B*51, B*15, B*40, B*35, DRB1*15, DR*09, DR*12, DR*04, DR*07 alleles in Hans of Shanxi were significantly higher and displayed distinctive distribution profiles when compared with those of Caucasian and Afro-American.
Conclusion:
The HLA-A,-B,-DRB1 distribution in Shanxi Han population shares some genetic characteristics with other Han populations in northern part of China, but it exhibits its own characteristics.
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