Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Host microsatellite alleles in malaria predisposition?

Sonali Gaikwad1, Richa Ashma, Nirbhay Kumar

  • 1Central Forensic Science Laboratory, National DNA Analysis Centre, Kolkata-700014, West Bengal, India. sonali_gaikwad@rediffmail.com

Malaria Journal
|October 12, 2005
PubMed
Summary

Microsatellite alleles in humans are linked to malaria susceptibility and resistance. Specific alleles of TH01 and D5S818 microsatellites influence Plasmodium falciparum infection risk, with some evolving recently due to selective pressures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-malarial contact dependent blocking of transmission of Plasmodium vivax by Anopheles darlingi mosquito vector.

PLoS pathogens·2026
Same author

Skin microbiota variation among Indian monozygotic twins.

PeerJ·2026
Same author

Determinants of Vitamin D in Indian Populations: Understanding the Interplay of Skin Pigmentation, Sun Exposure, and Genetic Variants.

American journal of human biology : the official journal of the Human Biology Council·2026
Same author

Hormone- and cytokine-mediated signalling in the maintenance of bone balance.

Journal of molecular endocrinology·2026
Same author

Arsenic Bioaccumulation in Cattle Naturally Exposed to Geogenic Groundwater Contamination in the Middle Indo-Gangetic Plains of Bihar.

Bulletin of environmental contamination and toxicology·2026
Same author

Sweat-prints of COVID-19: unique metabolite signatures.

Biomarkers in medicine·2025

Area of Science:

  • Human genetics
  • Population genetics
  • Infectious disease genetics

Background:

  • Malaria, caused by Plasmodium, is a severe disease affecting red blood cells.
  • Host genetic variations, including G6PD and beta-globin gene variants, are known to influence malaria resistance.
  • Polymorphic microsatellites contribute to human genetic diversity and may play a role in combating disease stress.

Purpose of the Study:

  • To investigate the hypothesis that microsatellite alleles (TH01 and D5S818) are associated with malaria predisposition.
  • To analyze the association between specific microsatellite alleles and malaria infection.
  • To perform population genetic analyses (structure analysis, AMOVA) to mitigate confounding effects of population stratification.

Main Methods:

  • Statistical association tests including recombination rate, Chi-square, and likelihood tests were employed.

Related Experiment Videos

  • Population genetic structure was investigated using AMOVA (Analysis of Molecular Variance).
  • Microsatellite allele frequencies were analyzed in relation to malaria infection status.

    • Main Results:

    • A positive association was found between alleles-13 (D5S818) and 9 (TH01) with increased susceptibility to Plasmodium falciparum.
    • Alleles-12 (D5S818) and 6 (TH01) were associated with resistance to malaria.
    • Microsatellite allele associations with malaria were validated, showing low genetic variance and no significant population stratification.

    Conclusions:

    • Specific microsatellite alleles confer varying degrees of susceptibility or resistance to malaria.
    • The evolution of malaria-resistant allele-6 (TH01) appears to be a recent event, potentially driven by Plasmodium-related selective forces.
    • Microsatellites act as a genetic buffer against disease stress, with implications for understanding host-parasite co-evolution.