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Related Experiment Videos

Type III secretion: the bacteria-eukaryotic cell express.

Luís Jaime Mota1, Isabel Sorg, Guy R Cornelis

  • 1Biozentrum der Universität Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland.

FEMS Microbiology Letters
|October 12, 2005
PubMed
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Type III secretion (T3S) is a bacterial nanomachine that injects proteins into host cells. This review covers T3S machinery, translocation pores, secretion signals, chaperones, and control mechanisms, highlighting future research directions.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Cell Biology

Background:

  • Type III secretion (T3S) is a critical virulence mechanism used by Gram-negative bacteria.
  • This system injects effector proteins directly into the host cell cytoplasm.
  • Understanding T3S is crucial for developing novel antimicrobial strategies.

Purpose of the Study:

  • To provide a comprehensive review of the Type III secretion system.
  • To highlight key features including the secretion nanomachine, translocation pore, and secretion signals.
  • To identify open questions and future research avenues in T3S.

Main Methods:

  • Literature review of existing research on Type III secretion.
  • Analysis of the structural and functional components of the T3S machinery.

Related Experiment Videos

  • Discussion of the regulatory mechanisms governing T3S.

    • Main Results:

    • Detailed description of the T3S nanomachine, often resembling a flagellar structure with a needle.
    • Explanation of translocation pore formation by T3S substrates within the host cell membrane.
    • Identification of non-cleavable N-terminal secretion signals and the role of T3S chaperones.

    Conclusions:

    • The T3S pathway involves a complex nanomachine, translocation pore, specific signals, and chaperones.
    • Effective control mechanisms ensure timely and targeted protein delivery.
    • Significant opportunities exist for future research to further elucidate T3S mechanisms and therapeutic potential.